The Premarital Screening Test is performed for couples who are planning to get married and scans a range of most common genetic blood and infectious diseases such as sickle cell anemia, thalassemia, and hepatitis B, hepatitis C, HIV. The purpose of this test is; to reduce the risk of parents passing illness or genetic disorders to their children. It identifies a possible disease or carrier status in the parents and determines the tendency to pass it on to their children. For this reason, it is one of the most important tests in reducing the number of birth defects. Dangerous blood diseases that are inherited from parents to children are common in our country where the rate of consanguineous marriages is high. In this regard, pre-marital screening tests are of great importance as they enable the determination of the risk of the married couple to have a child with thalassemia or sickle cell anemia.

Conducting this test with pre-marital counseling can help to improve the quality life of married couples as well as strengthen family structures. Also, having this screening test before pregnancy can reassure couples that they are not carriers or help them to give conscious choice for pregnancy.
If a disease or carriage is detected in the mother or father, genetic counseling and PGT is recommended to the family before pregnancy. With PGD, healthy embryos that do not carry the disease or mutation is selected and therefore family can have a healthy child. It is recommended that pre-marital screening test performed 3 months before the date of marriage.

Other purposes and benefits of pre-marital screening test are as follows:

• Prevention of the spread of certain genetic (sickle cell anemia, thalassemia) and infectious diseases
• Provides the development of awareness about the concept of healthy marriage
• May reduce patient density in health institutes and blood banks
• Can protect the family from possible social and psychological problems

Premarital screening test includes the following:

• Complete blood count (CBC)
• Blood group (ABO & Rh typing)
• Hb Variants testing (Thalassemia, Sickle cell)
• G6PD
• Sexually transmitted diseases
• HIV
• Hepatitis B
• Hepatitis C
• Syphilis
• Other STDs (i.e gonorrhea, Chlamydia …)

Other testing might include:

• Male and Female fertility testing
• Karyotyping

https://financialtribune.com/articles/people/59263/premarital-genetic-testing-mandatory

Abdulbari Bener, Mariam Al-Mulla, Angus Clarke, 2019, Premarital Screening and Genetic Counseling Program: Studies from an Endogamous Population

https://www.moh.gov.sa/en/HealthAwareness/Beforemarriage/Pages/default.aspx